The project Patient Information System has been developed on PHP and MySQL. The main objective of this project Patient Information System is to manage the details of Patient, Medicines, Doctors, Tests, Treatments. It manages all the information about Patient, Reports, Treatments, Patient. The purpose of this system is to build an application program to reduce the manual work for keep to track of patient information and managing the Patient, Medicines, Reports, Doctors. It tracks all the details about the Doctors, Tests, Treatments. This system provides the searching facilities based on various factors like Patient, Doctors, Tests, Treatments. This project shows the information and description of the patient diseases. It generates the report on Patient, Medicines, Reports.